Lipids and Cellular Membranes in Amyloid Diseases

Lipids and Cellular Membranes in Amyloid Diseases

Addressing one of the biggest riddles in current molecular cell biology, this ground-breaking monograph builds the case for the crucial involvement of lipids and membranes in the formation of amyloid deposits. Tying together recent knowledge from in vitro and in vivo studes, and built on a sound biophysical and biochemical foundation, this overview brings the reader up to date with current models of the interplay between membranes and amyloid formation. Required reading for any researcher interested in amyloid formation and amyloid toxicity, and possible avenues for the prevention or treatment of neurodegenerative disorders. From the contents: * Interactions of Alpha-Synuclein with Lipids * Interaction of hIAPP and its Precursors with Membranes * Amyloid Polymorphisms: Structural Basis and Significance in Biology and Molecular Medicine * The Role of Lipid Rafts in Alzheimer's Disease * Alzheimer's Disease as a Membrane-Associated Enzymopathy of Beta-Amyloid Precursor Protein (APP) Secretases * Impaired Regulation of Glutamate Receptor Channels and Signaling Molecules by Beta-Amyloid in Alzheimer's Disease * Membrane Changes in BSE and Scrapie * Experimental Approaches and Technical Challenges for Studying Amyloid-Membrane Interactions and more


Author
Publisher John Wiley & Sons
Release Date
ISBN 3527634339
Pages 296 pages
Lipids and Cellular Membranes in Amyloid Diseases
Language: en
Pages: 296
Authors: Raz Jelinek
Categories: Science
Type: BOOK - Published: 2011-04-27 - Publisher: John Wiley & Sons

Addressing one of the biggest riddles in current molecular cell biology, this ground-breaking monograph builds the case for the crucial involvement of lipids an
Membrane Lipid Signaling in Aging and Age-Related Disease
Language: en
Pages: 236
Authors: M.P. Mattson
Categories: Science
Type: BOOK - Published: 2003-05-06 - Publisher: Elsevier

The lipids of cellular membranes not only serve roles in controlling the structure and fluidity of the membrane, but are increasingly recognized for their roles
Amyloid Fibrils and Prefibrillar Aggregates
Language: en
Pages: 464
Authors: Daniel Erik Otzen
Categories: Science
Type: BOOK - Published: 2013-06-04 - Publisher: John Wiley & Sons

Summing up almost a decade of biomedical research, this topical and eagerly awaited handbook is the first reference on the topic to incorporate recent breakthro
Lipids in Protein Misfolding
Language: en
Pages: 260
Authors: Olga Gursky
Categories: Science
Type: BOOK - Published: 2015-07-06 - Publisher: Springer

​Protein conversion from a water-soluble native conformation to the insoluble aggregates and fibrils, which can deposit in amyloid plaques, underlies more tha
Alzheimer's Disease: Cellular and Molecular Aspects of Amyloid beta
Language: en
Pages: 442
Authors: J. Robin Harris
Categories: Science
Type: BOOK - Published: 2004-12-17 - Publisher: Springer Science & Business Media

To understand Alzheimer's disease (AD) is one of the major thrusts of present-day clinical research, strongly supported by more fimdamental cellular, biochemica
Insights in Brain Disease Mechanisms: 2021
Language: en
Pages: 256
Authors: Detlev Boison
Categories: Science
Type: BOOK - Published: 2022-11-21 - Publisher: Frontiers Media SA

Lipid-Protein Mesophases and Cell Organelle Ultrastructure in Health and Disease
Language: en
Pages: 239
Authors: Yuru Deng
Categories: Science
Type: BOOK - Published: 2021-11-29 - Publisher: Frontiers Media SA

Emerging Mechanisms in Neuronal Signaling: From Cell Biology to Pathogenesis
Language: en
Pages: 454
Authors: Mario Eduardo Guido
Categories: Science
Type: BOOK - Published: 2020-11-12 - Publisher: Frontiers Media SA

This eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series:
Bio-nanoimaging
Language: en
Pages: 552
Authors: Vladimir Uversky
Categories: Technology & Engineering
Type: BOOK - Published: 2013-11-05 - Publisher: Academic Press

Bio-Nanoimaging: Protein Misfolding & Aggregation provides a unique introduction to both novel and established nanoimaging techniques for visualization and char
Brain Lipids in Synaptic Function and Neurological Disease
Language: en
Pages: 398
Authors: Jacques Fantini
Categories: Medical
Type: BOOK - Published: 2015-07-01 - Publisher: Academic Press

Lipids are the most abundant organic compounds found in the brain, accounting for up to 50% of its dry weight. The brain lipidome includes several thousands of